Included in this article:

How CryoDerm Works to Relieve Pain

Unsafe Ingredients in Other Products


How CryoDerm Works to Relieve Pain

CryoDerm products relieve pain by breaking the Pain-Spasm Cycle. This is a physiological cycle in which sensations and cognitions of pain from injury cause spasm in the nearby muscles. The spasm causes several other reactions in the body which in turn create more feelings of pain. This cycle continues indefinitely unless broken. The following diagrams explain how the Pain-Spasm cycle occurs without intervention, and how the cycle is broken using CryoDerm.


 Without CryoDerm

Without CryoDerm

(1) When we are injured, a pain signal is sent to the brain to communicate the injury. (2) This pain signal causes the muscles in the area of injury to involuntarily contract and remain contracted as a guarding mechanism. (3) This sustained contraction causes an ischemic condition (decreased blood flow and oxygen supply) as well as decreased lymphatic drainage. (4) The lack of oxygen in the area means that energy production using oxygen (Krebs Cycle) cannot be completed. (5) This causes a buildup of metabolic waste products including lactic acid. (6) The buildup of waste products creates more pain signals and cramping, which begins the cycle again.

 With CryoDerm

With CryoDerm


(1) CryoDerm offers a cold sensation to counteract feelings of pain. The ingredients used inour product activate The Gate Control Theory, in which CryoDerm’s cold signal beats the pain signal to the brain. (2) Without the feeling of pain, the muscles can release their contraction, (3) allowing blood and oxygen to flow back into the injured area. (4) With oxygen, energy production through the Krebs Cycle can continue, (5) and the venous and lymphatic drainage systems can work to remove metabolic waste buildup. (6) Without the buildup of metabolic waste, the feelings of pain decrease, and the cycle has been broken!





Unsafe Ingredients in Other Topical Products

CryoDerm is proud to use ingredients that are certified gluten-free and eco-friendly. The topical products are also free of silicone, dyes, isopropyl alcohol, parabens, and methyl salicylate.

Be cautious if any products you are using contain any of the following ingredients as there are possible health effects. Please ensure that you consult a healthcare professional prior to use.

Methyl Salicylate
Methyl Salicylate has similar effects to aspirin and other blood-thinners. Products containing methyl salicylate should not be used for more than 7 consecutive days and should not be applied to skin that is warm or hot. Warm skin will allow excessive absorption of the product into the blood stream. Overuse of this product, or when used in conjunction with other medications such as blood-thinners may lead to a buildup of methyl salicylate in the blood stream. This buildup can lead to overdose, kidney failure, difficulty breathing, convulsions, and on some occasions, death. There has been at least 1 documented case in the United States of a methyl salicylate overdose leading to death.

Used in many topical analgesics to add colour. Dyes may stain clothing, skin, and can cause irritation. Currently, there are concerted efforts to ban the use of dyes in food and topical preparations.

Used in some products to thicken the solution and enhance glide. This inexpensive product blocks pores, can trap bacteria, and cause skin dryness and irritation.

Isopropyl Alcohol
Known most commonly as rubbing alcohol. Used in some products to keep crystallized menthol in a liquid state. It is produced by combining water with propene. This ingredient can be toxic, instructions on bottles mention not using on large areas of the body, or for more than one consecutive week as it can cause damage to the colon, kidneys, liver, skin, and central nervous system (CNS).

Isopropyl Alcohol evaporates very quickly on the skin, producing an instant cooling sensation. The formula remains at skin surface level as isopropyl alcohol does not allow the product to penetrate deeper into the tissue.

CryoDerm uses denatured grain alcohol, a natural ingredient. This form of alcohol does not evaporate as quickly as isopropyl alcohol which is why the cooling sensation of CryoDerm may takes a minute or two to activate. The benefit of using denatured grain alcohol is that the product is able to penetrate deeper layers to provide thorough relief.


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